relaxed and cheerful as he pushed his wife in in her chair. She was sitting
with her legs dangling down, smiling as well. I immediately knew that she
was a lot better. I began to ask her about her various symptoms she had had
previously. After a few minutes she impatiently broke in to say, "Dr.
Hoffer, the pain in my back is all gone." She no longer bled from her bowel,
she no longer bruised all over her body, she was more comfortable, the pain
in her back was easily controlled with aspirin and was gone from her hips,
(it had not helped before). She was cheerful and laughed in my office. Her
heart was regular at last. I added inositol niacinate 500 mg four times
daily to her program.
She came back June 17, 1982, and had improved even more. She was able to
pull herself up from the prone position on her bed for the first time in 15
years, and she was free of depression. I increased her ascorbic acid to 1
gram four times daily and added vitamin E 800 IU. Because she had shown such
dramatic improvement I advised her she need no longer come to see me.
September 1, 1982, she called me on the telephone. I asked her how she was
getting along. She said she was making even more progress. I then asked her
how had she been able to get to the phone. She replied she was able to get
around alone in her chair. Then she added she had not called for herself but
for her husband. He had been suffering from a cold for a few days, she was
nursing him, and she wanted some advice for him.
After another visit October 28, 1983, I wrote to her doctor "Today Mrs. K.V.
reported she had stayed on the whole vitamin program very rigorously for 18
months, but since that time had slacked off somewhat. She is regaining a lot
of her muscle strength, can now sit in her wheelchair without difficulty,
can also wheel herself around in her wheelchair but, of course, can not do
anything useful with her hands because her fingers are so awful. She would
like to become more independent and perhaps could do so if something could
be done about her fingers and also about her hip. I am delighted she has
arranged to see a plastic surgeon to see if something can be done to get her
hand mobilized once more. I have asked her to continue with the vitamins but
because she had difficulty taking so many pills she will take a preparation
called Multijet which is available from Portland and contains all the
vitamins and minerals and can be dissolved in juice. She will also take
inositol niacinate 3 grams daily."
I saw her again March 24, 1988. About 4 of her vertebra had collapsed and
she was suffering more pain which was alleviated by Darvon. It had not been
possible to treat her hands surgically. She had been able to eat by herself
until six months before this last visit. She had been taking small amounts
of vitamins. She was able to use a motorized chair. She had been depressed.
I wrote to her doctor, "She had gone off the total vitamin program about two
or three years ago. It is very difficult for her to swallow and I can
understand her reluctance to carry on with this. I have therefore suggested
that she take a minimal program which would include inositol niacinate 3
grams daily, ascorbic acid 1 gram three times, linseed oil 2 capsules and
cod liver oil 2 capsules. Her spirits are good and I think she is coming
along considering the severe deterioration of her body as a result of the
arthritis over the past few decades." She was last seen by her doctor in the
fall of 1989.
Her husband was referred. I saw him May 18, 1982. He complained of headaches
and a sense of pressure about his head present for three years. This
followed a series of light strokes. I advised him to take niacin 3 grams
daily plus other vitamins including vitamin C. By September 1983 he was well
and when seen last March 24, 1988 was still normal.
3. Juvenile Diabetes
Dr. Robert Elliot, Professor of Child Health Research at University of
Auckland Medical School is testing 40,000 five-year old children for the
presence of specific antibodies that indicate diabetes will develop. Those
who have the antibodies will be given nicotinamide. This will prevent the
development of diabetes in most the children who are vulnerable. According
to the Rotarian for March 1993 this project began 8 years ago and has 3200
relatives in the study. Of these, 182 had antibodies and 76 were given
nicotinamide. Only 5 have become diabetic compared to 37 that would have
been expected. Since 1988 over 20,100 school children have been tested. None
have become diabetic compared to 47 from the untested comparable group. A
similar study is underway in London, Ontario.
4. Cancer
Recent findings have shown that vitamin B-3 does have anti-cancer
properties. This was discussed at a meeting in Texas in 1987, Jacobson and
Jacobson. [15] The topic of this international conference was "Niacin,
Nutrition, ADP-Ribosylation and Cancer," and was the 8th conference of this
series.
Niacin, niacinamide and nicotinamide adenine dinucleotide (NAD) are
interconvertable via a pyridine nucleotide cycle. NAD, the coenzyme, is
hydrolyzed or split into niacinamide and adenosine dinucleotide phosphate
(ADP-ribose). Niacinamide is converted into niacin, which in turn is once
more built into NAD. The enzyme which splits ADP is known as poly
(ADP-ribose) polymerase, or poly (ADP) synthetase, or poly (ADP-ribose)
transferase. Poly (ADP-ribose) polymerase is activated when strands of
deoxyribonucleic acid (DNA) are broken. The enzyme transfers NAD to the
ADP-ribose polymer, binding it onto a number of proteins. The poly
(ADP-ribose) activated by DNA breaks helps repair the breaks by unwinding
the nucleosomal structure of damaged chromatids. It also may increase the
activity of DNA ligase. This enzyme cuts damaged ends off strands of DNA and
increases the cell's capacity to repair itself. Damage caused by any
carcinogenic factor, radiation, chemicals, is thus to a degree neutralized
or counteracted.
Jacobson and Jacobson, conference organizers, hypothesized that niacin
prevents cancer. They treated two groups of human cells with carcinogens.
The group given adequate niacin developed tumors at a rate only 10% of the
rate in the group deficient in niacin. Dr. M. Jacobson is quoted as saying,
"We know that diet is a major risk factor, that diet has both beneficial and
detrimental components. What we cannot assess at this point is the optimal
amount of niacin in the diet... The fact that we don't have pellagra does
not mean we are getting enough niacin to confer resistance to cancer." About
20 mg per day of niacin will prevent pellagra in people who are not chronic
pellagrins. The latter may require 25 times as much niacin to remain free of
pellagra.
Vitamin B-3 may increase the therapeutic efficacy of anti-cancer treatment.
In mice, niacinamide increased the toxicity of irradiation against tumors.
The combination of normobaric carbogen with nicotinamide could be an
effective method of enhancing tumor radiosensitivity in clinical
radiotherapy where hypoxia limits the outcome of treatment. Chaplin, Horsman
and Aoki16 found that nicotinamide was the best drug for increasing
radiosensitivity compared to a series of analogues. The vitamin worked
because it enhanced blood flow to the tumor. Nicotinamide also enhanced the
effect of chemotherapy. They suggested that niacin may offer some
cardioprotection during long-term adriamycin chemotherapy.
Further evidence that vitamin B-3 is involved in cancer is the report by
Nakagawa, Miyazaki, Okui, Kato, Moriyama and Fujimura [17] that in animals
there is a direct relationship between the activity of nicotinamide methyl
transferase and the presence of cancer. Measuring the amount of N-methyl
nicotinamide was used to measure the activity of the enzyme. In other words,
in animals with cancer there is increased destruction of nicotinamide, thus
making less available for the pyridine nucleotide cycle. This finding
applied to all tumors except the solid tumors, Lewis lung carcinoma and
melanoma B-16.
Gerson [18] treated a series of cancer patients with special diets and with
some nutrients including niacin 50 mg 8 to 10 times per day, dicalcium
phosphate with vitamin D, vitamins A and D, and liver injections. He found
that all the cancer cases were benefited in that they became healthier and
in many cases the tumors regressed. In a subsequent report Gerson elaborated
on his diet. He now emphasized a high potassium over sodium diet, ascorbic
acid, niacin, brewers yeast and lugols iodine. Right after the war there was
no ready supply of vitamins as there is today. I would consider the use of
these nutrients in combination very original and enterprising. Dr. Gerson
was the first physician to emphasize the use of multivitamins and some
multiminerals. More details are
in Hoffer. [19]
Additional evidence that vitamin B-3 is therapeutic for cancer arises from
the National Coronary Study, Canner. [2]
5. Concentration Camp Survivors
In 1960 I planned to study the effect of nicotinic acid on a large number of
aging people living in a sheltered home. A new one had been built. I
approached the director of this home, Mr. George Porteous. I arranged to
meet him and told him what I would like to do and why. I gave him an outline
of its properties, its side effects and why I thought it might be helpful.
Mr. Porteous agreed and we started this investigation. A short while after
my first contact Mr. Porteous came to my office at University Hospital. He
wanted to take nicotinic acid himself, he told me, so that he could discuss
the reaction more intelligently with people living in his institution. He
wanted to know if it would be safe to do so.
That fall he came again to talk to me and this time he said he wanted to
tell me what had happened to him. Then I discovered he had been with the
Canadian troops who had sailed to Hong Kong in 1940, had been promptly
captured by the Japanese and had survived 44 months in one of their
notorious prisoner of war camps.
Twenty-five percent of the Canadian soldiers died in these camps. They
suffered from severe malnutrition from starvation and nutrient deficiency.
They suffered from beri beri, pellagra, scurvy, infectious diseases, and
brutality from the guards.
Porteous, a physical education instructor, had been fit weighing about 190
pounds when he got there. When he returned home he weighed only 2/3rds of
that. On the way home in a hospital ship the soldiers were fed and given
extra vitamins in the form of rice polishings. There were few vitamins
available then in tablets or capsules. He seemingly recovered but had
remained very ill. He suffered from both psychological and physical
symptoms. He was anxious, fearful and slightly paranoid. Thus, he could
never be comfortable sitting in a room unless he sat facing the door. This
must have arisen from the fear of the guards. Physically he had severe
arthritis. He could not raise his arms above his shoulders. He suffered from
heat and cold sensitivity. In the morning he needed his wife's help in
getting out of bed and to get started for the day. He had severe insomina.
For this he was given barbiturates in the evening and to help awaken him in
the morning, he was given amphetamines.
Later I read the growing literature on the Hong Kong veterans and there is
no doubt they were severely and permanently damaged. They suffered from a
high death rate due to heart disease, crippling arthritis, blindness and a
host of other conditions.
Having outlined his background he then told me that two weeks after he
started to take nicotinic acid, 1 gram after each meal, he was normal. He
was able to raise his arms to their full extension, and he was free of all
the symptoms which had plagued him for so long. When I began to prepare my
report [20] I obtained his Veterans Administration Chart. It came to me in
two cardboard boxes and weighed over ten pounds, but over 95% of it was
accumulated before he started on the vitamin. For the ten years after he
started on the vitamin there was very little additional material. One could
judge the efficacy of the vitamin by weighing the chart paper before and
after he started on it. Porteous remained well as long as he stayed on the
vitamin until his death when he was Lieutenant Governor of Saskatchewan. In
1962, after having been well for two years, he went on a holiday to the
mountains with his son and he forgot to take his nicotinic acid with him. By
the time he returned home almost the entire symptomatology had returned.
Porteous was enthusiastic about nicotinic acid and began to tell all his
friends about it. He told his doctor. His doctor cautioned him that he might
damage his liver. Porteous replied that if it meant he could stay as well as
he was until he died from a liver ailment he would still not go off it. His
doctor became an enthusiast as well and within a few years had started over
300 of his patients on the vitamin. He never saw any examples of liver
disease from nicotinic acid.
I have treated over 20 prisoners from Japanese camps and from European
concentration camps since then with equally good results. I estimated that
one year in these camps was equivalent to 4 years of aging, i.e. four years
in camp would age a prisoner the equivalent of 16 years of normal living.
George Porteous wanted every prisoner of war from the eastern camps treated
as he had been. He was not successful in persuading the Government of Canada
that nicotinic acid would be very helpful so he turned to fellow prisoners,
both in Canada (Hong Kong Veterans) and to American Ex-Prisoners of War.
These American veterans suffered just as much as had the Canadian soldiers
since they were treated in exactly the same abysmal way. The ones who
started on the vitamin showed the same response. Recently one of these
soldiers, a retired officer, wrote to me after being on nicotinic acid 20
years that he felt great, owed it to the vitamin and that when his arteries
were examined during a simple operation they were completely normal. He
wrote, "About two years ago, I was hit, was bleeding down the neck. The MDs
took the opportunity to repair me. They said the arteries under the ears
look like they had never been used."
There is an important lesson from the experiences of these veterans and
their response to megadoses of nicotinic acid. This is that every human
exposed to severe stress and malnutrition for a long enough period of time
will develop a permanent need for large amounts of this vitamin and perhaps
for several others.
This is happening on a large scale in Africa where the combination of
starvation, malnutrition and brutality is reproducing the conditions
suffered by the veterans. Those who survive will be permanently damaged
biochemically, and will remain a burden to themselves and to the community
where they live. Will society have the good sense to help them recover by
making this vitamin available to them in optimum doses?
Doses
The optimum dose range is not as wide as it is for ascorbic acid, but it is
wide enough to require different recommendations for different classes of
diseases. As is always the case with nutrients, each individual must
determine their own optimum level. With nicotinic acid this is done by
increasing the dose until the flush (vasodilation) is gone, or is so slight
it is not a problem.
One can start with as low a dose as 100 mg taken three times each day after
meals and gradually increase it. I usually start with 500 mg each dose and
often will start with 1 gram per dose especially for cases of arthritis, for
schizophrenics, for alcoholics and for a few elderly patients. However, with
elderly patients it is better to start small and work it up slowly.
No person should be given nicotinic acid without explaining to them that
they will have a flush which will vary in intensity from none to very
severe. If this is explained carefully, and if they are told that in time
the flush will not be a problem, they will not mind. The flush may remain
too intense for a few patients and the nicotinic acid may have to be
replaced by a slow release preparation or by some of the esters, for
example, inositol niacinate. The latter is a very good preparation with very
little flush and most find it very acceptable even when they were not able
to accept the nicotinic acid itself. It is rather expensive but with
quantity production the price might come down.
The flush starts in the forehead with a warning tingle. Then it intensifies.
The rate of the development of the flush depends upon so many factors it is
impossible to predict what course it will follow.
The following factors decrease the intensity of the flush: a cold meal,
taking it after a meal, taking aspirin before, using an antihistamine in
advance.
The following factors make the flush more intense: a hot meal, a hot drink,
an empty stomach, chewing the tablets and the rate at which the tablets
break down in liquid.
From the forehead and face the flush travels down the rest of the body,
usually stopping somewhere in the chest but may extend to the toes. With
continued use the flush gradually recedes and eventually may be only a
tingling sensation in the forehead. If the person stops taking the vitamin
for a day or more the sequence of flushing will be re-experienced. Some
people never do flush and a few only begin to flush after several years of
taking the vitamin. With nicotinamide there should be no flushing but I have
found that about 2% will flush. This may be due to rapid conversion of the
nicotinamide to nicotinic acid in the body.
When the dose is too high for both forms of the vitamin the patients will
suffer from nausea at first, and then if the dose is not reduced it will
lead to vomiting. These side effects may be used to determine what is the
optimum dose. When they do occur the dose is reduced until it is just below
the nausea level. With children the first indication may be loss of
appetite. If this does occur the vitamin must be stopped for a few days and
then may be resumed at a lower level. Very few can take more than 6 grams
per day of the nicotinamide. With nicotinic acid it is possible to go much
higher. Many schizophrenics have taken up to 30 grams per day with no
difficulty. The dose will alter over time and if on a dose where there were
no problems, they may develop in time. Usually this indicates that the
patient is getting better and does not need as much. I have divided all
patients who might benefit from vitamin B-3 into the following categories.
Category 1. These are people who are well or nearly well, and have no
obvious disease. They are interested in maintaining their good health or in
improving it. They may be under increased stress. The optimum dose range
varies between 0.5 to 3 grams daily. The same doses apply to nicotinamide.
Category 2. Everyone under physiological stress, such as pregnancy and
lactation, suffering from acute illness such as the common cold or flu, or
other diseases that do not threaten death. All the psychiatric syndromes are
included in this group including the schizophrenias and the senile states.
It also includes the very large group of people with high blood cholesterol
levels or low HDL when it is desired to restore these blood values to
normal. The dose range is 1 gram to 10 grams daily. For nicotinamide the
range is 1 1/2 g to 6 g.
Nicotinamide does not affect cholesterol levels.
Side Effects
Here are Dr. John Marks' conclusions. [21]
"A tingling or flushing sensation in the skin after relatively large doses
(in excess of 75 mg) of nicotinic acid is a rather common phenomenon. It is
the result of dilation of the blood vessels that is one of the natural
actions of nicotinic acid and one for which it is used therapeutically.
Whether this should therefore be regarded as a true adverse reaction is a
moot point. The reaction clears regularly after about 20 minutes and is not
harmful to the individual. It is very rare for this reaction to occur at
less than three times the RDA, even in very sensitive individuals. In most
people much larger quantities are required. The related substance
nicotinamide only very rarely produces this reaction and in consequence this
is the form generally used for vitamin supplementation.
"Doses of 200 mg to 10 g daily of the acid have been used therapeutically to
lower blood cholesterol levels under medical control for periods of up to 10
years or more and though some reactions have occurred at these very high
dosages, they have rapidly responded to cessation of therapy, and have often
cleared even when therapy has been continued.
"In isolated cases, transient liver disorders, rashes, dry skin and
excessive pigmentation have been seen. The tolerance to glucose has been
reduced in diabetics and patients with peptic ulcers have experienced
increased pain. No serious reaction have been reported however even in these
high doses. The available evidence suggests that 10 times the RDA is safe
(about 100 mg)."
Dr. Marks is cautious about recommending that doses of 100 mg are safe. In
my opinion, based upon 40 years of experience with this vitamin the dose
ranges I have recommended above are safe. However with the higher doses
medical supervision is necessary.
Jaundice is very rare. Fewer that ten cases have been reported in the
medical literature. I have seen none in ten years. When jaundice dose occur
it is usually an obstructive type and clears when the vitamin is
discontinued. I have been able to get schizophrenic patients back on
nicotinic acid after the jaundice cleared and it did not recur.
Four serious cases have been reported, all involving a sustained release
preparation. Mullin, Greenson & Mitchell (1989) [22] reported that a 44
year-old man was treated with crystalline nicotinic acid, 6 grams daily, and
after 16 months was normal. He then began to take a sustained-release
preparation, same dose. Within three days he developed nausea, vomiting,
abdominal pain, dark urine. He had severe hepatic failure and required a
liver transplant. Henkin, Johnson & Segrest found three patients who
developed hepatitis with sustained release nicotinic acid. When this was
replaced with crystalline nicotinic acid there was no recurrent liver
damage. [23]
Since jaundice in people who have not been taking nicotinic acid is fairly
common it is possible there is a random association. The liver function
tests may indicate there is a problem when in fact there is not. Nicotinic
acid should be stopped for five days before the liver function tests are
given. One patient who had no problem with nicotinic acid for lowering
cholesterol switched to the slow release preparations and became ill. When
he resumed the original nicotinic acid he was well again with no further
evidence of liver dysfunction. I have not seen any cases reported anywhere
else. I have described much more fully the side effects of this vitamin
elsewhere. [24]
Inositol hexaniacinate is an ester of inositol and nicotinic acid. Each
inositol molecule contains six nicotinic acid molecules. This ester is
broken down slowly in the body. It is as effective as nicotinic acid and is
almost free of side effects. There is very little flushing, gastrointestinal
distress and other uncommon side effects. Inositol, considered one of the
lesser important B vitamins, does have a function in the body as a messenger
molecule and may add something to the therapeutic properties of the
nicotinic acid.
Conclusion
Vitamin B-3 is a very effective nutrient in treating a large number of
psychiatric and medical diseases but its beneficial effect is enhanced when
the rest of the orthomolecular program is included. The combination of
vitamin B-3 and the antioxidant nutrients is a great anti-stress program.
Reprinted with the permission of the author:
Abram Hoffer, M.D., Ph.D.
Suite 3 - 2727 Quadra St
Victoria, British Columbia V8T 4E5 Canada
References
1. Horwitt MK: Modern Nutrition in Health and Disease. Fifth Ed. RS Goodhart
and ME Shils. Lea & Febiger, Phil. 1974.
2. Canner PL, Berge KG, Wenger NK, Stamler J, Friedman L, Prineas RJ &
Freidewald W: Fifteen year mortality Coronary Drug Project; patients long
term benefit with niacin. American Coll Cardiology 8:1245-1255, 1986.
3. Altschul R, Hoffer A & Stephen JD: Influence of Nicotinic Acid on Serum
Cholesterol in Man. Arch Biochem Biophys 54:558-559, 1955.
4. Hoffer A: The Schizophrenia, Stress and Adrenochrome Hypothesis. In
Press, 1995.
5. Hoffer A: Orthomolecular Medicine for Physicians. Keats Pub, New Canaan,
CT, 1989.
6. Hoffer A: The treatment of schizophrenia. In Press 1995.
7. Hoffer A: The Development of Orthomolecular Medicine. In Press, 1995.
8. Hoffer A: Niacin Therapy in Psychiatry. C. C. Thomas, Springfield, IL,
1962.
Hoffer A & Osmond H: New Hope For Alcoholics, University Books, New York,
1966. Written by Fannie Kahan.
Hoffer A & Walker M: Nutrients to Age Without Senility. Keats Pub Inc, New
Canaan, CT, 1980.
Hoffer A & Walker M: Smart Nutrients. A Guide to Nutrients That Can Prevent
and Reverse Senility. Avery Publishing Group, Garden City Park, New York,
1994.
9. Agnew N & Hoffer A: Nicotinic Acid Modified Lysergic Acid Diethylamide
Psychosis. J Ment Science 101:12-27, 1955.
10. Ivanova RA, Milstein GT, Smirnova LS & Fantchenko ND: The Influence of
Nicotinic Acid on an Experimental Psychosis Produced by LSD 25. Journal of
Neuropathology and Psychiatry of CC Korsakoff 64:1172-1176, 1964. In
Russian. Translated by Dr. T.E. Weckowicz.
11. Wilson B: The Vitamin B-3 Therapy: The First Communication to A.A.'s
Physicians and A Second Communication to A.A.'s Physicians, 1967 and 1968.
12. Smith RF: A five year field trial of massive nicotinic acid therapy of
alcoholics in Michigan. Journal of Orthomolecular Psychiatry 3:327-331,
1974.
Smith RF: Status report concerning the use of megadose nicotinic acid in
alcoholics. Journal of Orthomolecular Psychiatry 7:52-55, 1978.
13. Kaufman W: Common Forms of Niacinamide Deficiency Disease: Aniacin
Amidosis. Yale University Press, New Haven, CT, 1943.
Kaufman W: The Common Form of Joint Dysfunction: Its Incidence and
Treatment. E.L. Hildreth and Co., Brattelboro, VT, 1949.
14. Hoffer A: Orthomolecular Medicine For Physicians, Keats Pub, New Canaan,
CT, 1989.
15. Jacobson M & Jacobson E: Niacin, nutrition, ADP-ribosylation and cancer.
The 8th International Symposium on ADP- Ribosylation, Texas College of
Osteopathic Medicine, Fort Worth, TX, 1987.
Titus K: Scientists link niacin and cancer prevention. The D.O. 28:93-97,
1987.
Hostetler D: Jacobsons put broad strokes in the niacin/cancer picture. The
D.O. 28:103-104, 1987.
16. Chaplin DJ, Horsman MP & Aoki DS: Nicotinamide, Fluosol DA and Carbogen:
a strategy to reoxygenate acutely and chronically hypoxic cells in vivo.
British Journal of Cancer 63:109-113, 1990.
17. Nakagawa K, Miyazaka M, Okui K, Kato N, Moriyama Y & Fujimura S:
N1-methylnicotinamide level in the blood after nicotinamide loading as
further evidence for malignant tumor burden. Jap. J. Cancer Research
82:277-1283, 1991.
18. Gerson M: Dietary considerations in malignant neoplastic disease. A
prelimary report. The Review of Gastroenterology 12:419-425, 1945.
Gerson M: Effects of a combined dietary regime on patients with malignant
tumors. Experimental Medicine and Surgery 7:299-317, 1949.
19. Hoffer A: Orthomolecular Oncology. In, Adjuvant Nutrition in Cancer
Treatment, Ed. P. Quillin & R. M. Williams. 1992 Symposium Proceedings,
Sponsored by Cancer Treatment Research Foundation and American College of
Nutrition. Cancer Treatment Research Foundation, 3455 Salt Creek Lane, Suite
200, Arlington Heights, IL 60005-1090, 331-362, 1994.
20. Hoffer A: Hong Kong Veterans Study. J Orthomolecular Psychiatry 3:34-36,
1974.
21. Marks J: Vitamin Safety. Vitamin Information Status Paper, F. Hoffman La
Roche & Co., Basle, 1989.
22. Mullin GE, Greenson JK & Mitchell MC: Fulminant hepatic failure after
ingestion of sustained-release nicotinic acid. Ann Internal Medicine
111:253-255, 1989.
23. Henkin Y, Johnson KC & Segrest JP: Rechallenge with crystalline niacin
after drug-induced hepatitis from sustained-release niacin. J. American
Medical Assn. 264:241-243, 1990.
24. Hoffer A: Niacin Therapy in Psychiatry. C. C. Thomas, Springfield, IL,
1962.
Hoffer A: Safety, Side Effects and Relative Lack of Toxicity of Nicotinic
acid and Nicotinamide. Schizophrenia 1:78-87, 1969.
Hoffer A: Vitamin B-3 (Niacin) Update. New Roles For a Key Nutrient in
Diabetes, Cancer, Heart Disease and Other Major Health Problems. Keats Pub,
Inc., New Canaan, CT, 1990.
[Non-text portions of this message have been removed]
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++++Message 5641. . . . . . . . . . . . Re: State liquor agency mentioned in
Doctor Bob''s Nightmare
From: Glenn F. Chesnut . . . . . . . . . . . . 4/18/2009 2:39:00 PM
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In message #5631
http://health.groups.yahoo.com/group/AAHistoryLovers/message/5631
there are two key paragraphs in the newspaper article which is cited there
from
the June 18, 1902 New York Times:
"The Selectmen of each town appoint a town agent for the dispensing of
liquors
upon prescription, and most of these agents, who take half the profits, vend
vile liquor and break the law by handing it out to any citizen whom they
know as
a neighbor, be he a drunkard or not, without the formality of asking to see
his
prescription."
"'Blind pigs' abound, and in the large towns outnumber any other single
class of
places of business. Bogus drug stores with barrooms in the rear are a
notable
feature of the appointments of these towns and cities. Drinking, therefore,
goes
on in Vermont as if there were no law against it; its extent is augmented by
the
secrecy and risk attached to it, but little or none of the liquor sold is
fit to
drink, and every drink purchased is a toast to disorder and a violation of
law."
It appears to me that the agents at the state liquor agencies whom Dr. Bob
was
referring to, were only allowed to dispense alcoholic beverages to people
who
had a doctor's prescription for it.
When I was a child, there were still country doctors who would tell people
with
heart conditions to drink a sip of whiskey every once in a while over the
course
of the day, to "calm their nerves" and "help their hearts." There were parts
of
India during the 1960's where alcoholic beverages were illegal unless you
had a
certificate from the physician certifying that you were an alcoholic! A
friend
from India said that there were a large number of people back home who had
talked a friendly physician into diagnosing them as alcoholics, even though
they
weren't.
Tommy H. has found a prescription for whiskey on eBay, a prescription
written by
a physician, dated July 31, 1928, written for a woman in Philadelphia,
Pennsylvania:
http://www.auctiva.com/hostedimages/showimage.aspx?gid=765521&image=25187733
7&im\
ages=251877337,251877379,251877417&formats=0,0,0&format=0 [8]
So it sounds like you had to have a doctor's prescription for the alcohol in
Vermont at that period -- OR -- and this "or" was the operant word -- have a
friendly local Vermont liquor agent who would wink his eye and write down on
his
books that you were an alcoholic who was starting to go into the DT's, so
you
could get a pint of whiskey from him.
Are there any New England historians who know whether this guess on my part
might be correct?
Glenn C. (South Bend, Indiana)
--- In AAHistoryLovers@yahoogroups.com, "aadavidi" wrote:
>
> In "DOCTOR BOB'S NIGHTMARE" is the following
> statement (Big Book page 171):
>
> "No beer or liquor was sold in the neighborhood, except at the State
liquor
agency where perhaps one might procure a pint if he could convince the agent
that he really needed it. Without this proof the expectant purchaser would
be
forced to depart empty handed with none of what I later came to believe was
the
great panacea for all human ills. Men who had liquor shipped in from Boston
or
New York by express were looked upon with great distrust and disfavor by
most of
the good townspeople."
>
> Can anyone offer a clear description of the function of the Vermont State
liquor agency in the late 1800's and why a person couldn't purchase all he
or
she wanted?
>
> [Dr. Bob was born August 8, 1879 in St. Johnsbury, Vermont, where he was
raised. He graduated from Dartmouth College in Hanover, New Hampshire, in
1902.]
>
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++++Message 5642. . . . . . . . . . . . Book signed by Dr Bob and Bill W
From: kentedavis@aol.com . . . . . . . . . . . . 4/19/2009 9:01:00 AM
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I have heard of a 12th printing of the first
edition that was signed by both Dr Bob (his
whole name) and Bill Wilson (his whole name).
I was wondering if it was a one of a kind.
There were not that many times that Bill and
Bob were together with a book to sign,
especially signing their whole names.
Could this have been signed at the 1950
International Convention in 1950? This book
was also signed by Lois and Father Pfau.
Were there other times that Bill and Bob were
together that they might have signed a book?
Does anyone know of other occasions that when
Bill and Bob were together after the book was
published in 1939, other than the International
Convention in 1950?
Has anyone seen other books that were signed
by both Bill and Bob?
Kent D. 8/8/88
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++++Message 5643. . . . . . . . . . . . Red Bank, New Jersey, AA group
From: Stephen Aberle . . . . . . . . . . . . 4/19/2009 3:38:00 PM
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I am trying to trace the founding (or founders)
of the Red Bank Monday night group in Monmouth
County, New Jersey.
I had thought incorrectly that we were the 2nd
oldest group in New Jersey -- we will celebrate
the group's 68th anniversary in August. That
implies a founding date of August 1941.
But I have copies of older meeting books from
Dec 1941 and Sept 1942, and Red Bank is not
listed.
I know AA in NJ started at the 1st meeting in
Montclair on May 14th, 1939 and then went to
South Orange at the home of Herb Debevoise,
continuing what had been started in Montclair.
Some of the earliest AA members in Red Bank
include Bart Grimsley, Allen Gallagher, and
Millie B.
Any and all help appreciated! ... Thanx
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++++Message 5644. . . . . . . . . . . . Pathways to abstinence: positive
impact of A.A.
From: loranarcher . . . . . . . . . . . . 4/21/2009 12:52:00 PM
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I have posted the second Knol of my analysis
of 1992 Americans, diagnosed as alcohol
abuse/dependence,
1) who never attended AA,
2) AA drop outs and
3) AA continued.
This analysis is of abstinence outcome.
The Knol is PATHWAYS TO ABSTINENCE: IMPACT
OF ALCOHOLICS ANONYMOUS
http://knol.google.com/k/loran-archer/pathways-to-abstinence-impact-of/33nxp
ux3i\
mfog/6 [9]
Key findings were:
-The results of the present study support the
efficacy of the fellowship of Alcoholics
Anonymous to promote abstinence
-In 1992 Americans with alcohol use disorders
who continued to attend AA were more likely
to achieve abstinence (64%) than those who
dropped out of AA (37%) or those who never
attended AA (16%)
-Abstinence recovery status varies as a function
of increasing age and level of severity of
alcohol symptoms.
-The findings suggest that a substantial portion
of the "AA drop outs" attain sobriety or
abstinence after a period of AA membership and
maintain their abstinence without AA
-The unmet need for AA referral is concentrated
in the younger age groups, 35% in the 18-29
years group and 30% in the 30-39 years age group
- - - -
From the moderator
Important data from one of our best American
alcoholism researchers. Note especially:
64% of those who continue in A.A.
continue to stay sober.
Of those who attend A.A. for a while and
get sober there, but then stop attending
meetings. only 37% remain sober.
A.A. is not the only way to get sober and
stay sober, but only 16% of those who never
attended A.A. get sober and stay sober
(these people presumbably do that by going
to church instead, by act of sheer will
power, or whatever).
So what is the best way of getting sober, if
you are an alcoholic? Going to A.A. meetings.
What is the best way to maximize your chances
of staying sober, if you got sober in A.A.?
Continuing to go to A.A. meetings.
Glenn C. (South Bend, Indiana)
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++++Message 5645. . . . . . . . . . . . DR Silkworth
From: katiebartlett79 . . . . . . . . . . . . 4/21/2009 11:34:00 AM
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Hi everyone,
Katie from Big Book Study: The Way Out
Can anyone tell me why Dr. Silkworth become
intrested in the alcohol field?
Many thanks.
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++++Message 5646. . . . . . . . . . . . A.A.''s BB Celebrates 70 Years
From: Bill Lash . . . . . . . . . . . . 4/22/2009 8:18:00 AM
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A.A.'s 'Big Book' celebrates 70 years
Printed in 58 languages, volume has been credited with saving lives of
millions of people worldwide
By Jim Carney (Akron Beacon Journal staff writer)
Jim Carney can be reached at 330-996-3576 or jcarney@thebeaconjournal.com.
Find this article at: http://www.ohio.com/news/43240782.html
Published on Sunday, Apr 19, 2009
Gail L.'s hands rest on the old red book on a table in front of her.
The book, she tells you, saved her life and gave her "a life worth saving."
It is "God's story of his love for the alcoholic," she says.
Seven decades ago this month, Alcoholics Anonymous, also called the Big
Book, was published.
For 70 years it has helped millions of people worldwide support each other
while protecting their identity — thus the avoidance of last names.
Sometime this year, it is expected that the 30 millionth copy will be sold.
And as Gail, archivist at the Akron Alcoholics Anonymous office, sits over a
first edition of the book known and cherished by recovering people since its
publication in April 1939, she talks of the power of its words.
"It is a design for living that really works," said Gail, 60, sober for 31
years and archivist in Akron since 1983.
Alcoholics Anonymous was founded in Akron on June 10, 1935. Next year will
be the organization's 75th anniversary.
Every year in June, Akron hosts Founders Day and more than 12,000 people
from around the world converge to remember the founding of the A.A.
movement. Founders Day events this
year are June 12-14.
While A.A. does not keep formal membership lists, the group estimates there
are nearly 2 million members worldwide who gather in nearly 115,000 groups,
including about 1.2 million members in the United States who meet in nearly
54,000 groups.
The first-edition book, one of 4,800 first printings, is kept in a safe at
A.A.'s office at 775 N. Main St.
The rare copy was signed June 10, 1948, by A.A. co-founders Dr. Robert Smith
of Akron and New York stockbroker Bill Wilson.
An Akron member donated the book.
Also kept in the safe is Dr. Bob's copy of the manuscript.
The book has been printed in 58 languages, according to a spokeswoman at the
A.A. General Services offices in New York City.
Gail said the book is really a history text. She said Wilson wrote most of
the first 164 pages, which are still in the most current edition.
Included on those pages are the 12 steps that have become the basis of the
A.A. program.
Following the first 164 pages are individual stories, three-fifths of them
Akron people who told of their ''strength, experience and hope'' and their
recovery to sobriety through A.A., she said.
Many of the 18 personal stories included in the first edition were written
by a sober, former newspaper reporter named Jim, an A.A. publication said.
He, along with Smith, sought out stories of local people with good sobriety
records.
The newspaperman's story was included as well in a chapter titled The News
Hawk.
The fourth edition, which came out in 2001, includes two stories of Akron
people, Gail said.
Gift from God
The Rev. Samuel Ciccolini, executive director of Interval Brotherhood Home,
a drug and alcohol treatment facility in Coventry Township, said the book,
studied by those in recovery, is nothing short of a miracle.
"To me, the Big Book is an inspiration of God," said Ciccolini, 66, known to
many as Father Sam.
IBH will celebrate its 40th anniversary in 2010.
"You see its enduring, life-saving value and you know it had to be more than
two recovering men that were that brilliant that put something together. It
had to be in God's hands," he said.
Ciccolini said he recalls two alcoholics coming to talk to his class when he
was a student at Akron's St. Peter's School in the mid-1950s.
The two recovering men each carried a copy of the Big Book, he said.
Ciccolini recalls each man holding it up and saying, "This book saved our
lives."
Later, when he was a theology student, he said he read the book.
"What it has done to save lives is immeasurable," Ciccolini said.
The foreword to the first edition begins:
"'We, of Alcoholics Anonymous, are more than one hundred men and women who
have recovered from a seemingly hopeless state of mind and body. To show
other alcoholics precisely how we have recovered is the main purpose of this
book."
The book originally sold for $3.50. It goes for $6 now and will increase to
$8 on July 1.
Akronite Scott D., 61, a member of A.A. for a dozen years, has taken part in
a men's Big Book study group since then.
He said the group meets once a week and goes over the first 164 pages,
including the chapter Dr. Bob's Nightmare that tells Smith's story.
"We read the book and discuss it," he said.
Scott said a passage that "registers in my head is we have but a daily
reprieve based on the maintenance of our spiritual condition."
Gail said when she started going to A.A. meetings, she began reading right
away.
"I fell in love with the book," she said.
Gail said that when the book was written, the Akron A.A. community pushed to
call it The Way Out and the New York group thought it should be called
simply Alcoholics Anonymous.
The New York group won that argument.
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++++Message 5647. . . . . . . . . . . . Re: Dr. Silkworth
From: CloydG . . . . . . . . . . . . 4/21/2009 10:15:00 PM
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Here is a link that may be helpful:
http://aabibliography.com/historyofaa/silkworth/silkworth.htm
Clyde, alcoholic
----- Original Message -----
From: katiebartlett79
Subject: [AAHistoryLovers] DR Silkworth
Can anyone tell me why Dr. Silkworth become
interested in the alcohol field?
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++++Message 5648. . . . . . . . . . . . Are reproduction Grapevines
available?
From: diazeztone . . . . . . . . . . . . 4/23/2009 2:35:00 PM
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A lady wrote me from my website wanting a June 1940 Grapevine.
Does anybody know where to obtain well-done reproductions??
I include her message here:
Greetings from another AA in Kentucky .... You came up on Google. I'm
looking
for a 1949 Grapevine, June if possible, for yet another AA who is turning 60
this June, born in 1949. Please let me know if you have/know of any ....
Thanks!
Suzanne Warden
suzanne.warden at gmail
ld pierce
aabibliography.com
eztone at hotmail
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++++Message 5649. . . . . . . . . . . . San Quentin: (1) inmate Ricardo and
(2) Bill W.''s speech
From: jaxena77 . . . . . . . . . . . . 4/21/2009 6:54:00 PM
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Hello,
(1) I am looking for more background info on the San Quentin inmate Ricardo
who
worked with Warden Duffy to set up the prison group there.
Apparently, Ricardo was interviewed by a San Francisco journalist in 1943,
and
the interview was published in the San Francisco Call-Bullentin. Does anyone
have this interview?
(2) I am also curious if there is a recording or transcription or
description of
the content of Bill Wilson's speech at San Quentin in the 40s.
Thanks!
Jackie
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++++Message 5650. . . . . . . . . . . . Re: Dr. Silkworth
From: diazeztone . . . . . . . . . . . . 4/25/2009 12:21:00 PM
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Kate, there is a biography of Silkworth you
should seek out:
Silkworth: The Little Doctor Who Loved Drunks,
the Biography of William Duncan Silkworth, M.D.
by Dale Mitchel available at Hazelden
I was looking but I can't find my copy. I hope
I did not lend it out.
LD Pierce
aabibliography.com
--- In AAHistoryLovers@yahoogroups.com, "CloydG" wrote:
>
> Here is a link that may be helpful:
>
> http://aabibliography.com/historyofaa/silkworth/silkworth.htm
>
> Clyde, alcoholic
>
>
> ----- Original Message -----
> From: katiebartlett79
> Subject: [AAHistoryLovers] DR Silkworth
>
> Can anyone tell me why Dr. Silkworth become
> interested in the alcohol field?
>
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++++Message 5651. . . . . . . . . . . . Photos of the Akron (and Australian)
AA oldtimer Jim Scott
From: Glenn Chesnut . . . . . . . . . . . . 4/26/2009 3:14:00 PM
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From: "Gordy" (gordy8 at gmail.com)
Hi there, Gordy is my name ( Australian AA groups
http://www.aa-oztralia.com/ )
I am wondering if any of you have any pics of Jim Scott, he was an
Australian
and had a fair bit to do with the editing of the AA Big Book.
< From GFC, the moderator: this is the Jim
< Scott whose story was in the 1st edit. of
< the BB as "Traveler, Editor, Scholar," later
< revised and called "The News Hawk," see
< http://www.barefootsworld.net/origbbstories.html#jims
I am a sponsee of the AA Australia archival officer Ian J. and we have been
looking for photos of Jim Scott, we have one grainy pic of him but nothing
else.
He is a very important link to our fellowship in Australia and any
information
we can get re Jim would be very gratefully received.
I was hoping you folks might have or know of where we could get a good
quality
pic ... plus any info apart from the general run o' the mill stuff that is
around about him.
Thanks very much and keep up the good work
God Bless
Gordy dos 11th of April 1977
... another grateful recovering alcoholic!
AA OZ Unity Recovery website: http://www.aa-oztralia.com/
AA Southern Cross website: http://www.southerncrossaa.blogspot.com/
Australian AOIG website: http://home.vicnet.net.au/~aoig/
AA OZ Unity Recovery audio meeting room:
http://chat.paltalk.com/g2/group/520563537/
AA Southern Cross meeting room: http://chat.paltalk.com/g2/group/1171665356/
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++++Message 5652. . . . . . . . . . . . Re: Photos of the Akron (and
Australian) AA oldtimer Jim Scott
From: Jim Hoffman . . . . . . . . . . . . 4/26/2009 10:04:00 PM
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Hi there,
This is Maria , I just got a picture of Jim
Scott from Ray G., former Dr. Bob's Home
Archivist. Although this is pretty grainy
I'd be happy to send it to see if it is any
better than the one you have. It is 8 X 11.
Looks to be of the same one that is on:
http://www.barefootsworld.net/origbbstories.html#jims
Contact me directly at
(jhoffma6 at tampabay.rr.com)
Maria
----- Original Message -----
From: Glenn Chesnut
To: AAHistoryLovers group
From: "Gordy" (gordy8 at gmail.com)
Hi there, Gordy is my name ( Australian AA groups
http://www.aa-oztralia.com/ )
I am wondering if any of you have any pics of Jim Scott, he was an
Australian and had a fair bit to do with the editing of the AA Big Book.
< From GFC, the moderator: this is the Jim
< Scott whose story was in the 1st edit. of
< the BB as "Traveler, Editor, Scholar," later
< revised and called "The News Hawk," see
< http://www.barefootsworld.net/origbbstories.html#jims
I am a sponsee of the AA Australia archival officer Ian J. and we have
been looking for photos of Jim Scott, we have one grainy pic of him but
nothing
else.
He is a very important link to our fellowship in Australia and any
information we can get re Jim would be very gratefully received.
I was hoping you folks might have or know of where we could get a good
quality pic ... plus any info apart from the general run o' the mill stuff
that
is around about him.
Thanks very much and keep up the good work
God Bless
Gordy
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++++Message 5653. . . . . . . . . . . . Whoopee parties
From: tsirish1 . . . . . . . . . . . . 4/26/2009 4:08:00 PM
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Does anyone KNOW the context in which Bill was
referring to "plain ordinary whoopee parties"?
I don't want guesses or theories; I already have
them. I was looking for documented historical
fact. Thanks in advance. Keep the Faith!
BB Tim
- - - -
From the moderator:
One of the most famous Walt Disney cartoon
shorts of the 1930's was called "The Whoopee
Party."
A picture is worth a thousand words, go to
YouTube and watch the cartoon:
Mickey Cartoons — The Whoopee Party (Sept. 17, 1932)
http://www.youtube.com/watch?v=1d7zxYsl67I
Also look up whoopee party on wikipedia:
http://en.wikipedia.org/wiki/The_Whoopee_Party
GFC
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++++Message 5654. . . . . . . . . . . . Re: Are reproduction Grapevines
available? 1949 not 1940
From: diazeztone . . . . . . . . . . . . 4/25/2009 12:16:00 PM
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She needs June 1949 not 1940.
Sorry my typo.
LD Pierce
- - - -
Also from: "Keith"
(kroloson at mindspring.com)
The lady needs a JUNE 1949 year, Suzanne had a typo.
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++++Message 5655. . . . . . . . . . . . Re: Are reproduction Grapevines
available?
From: Tom Hickcox . . . . . . . . . . . . 4/24/2009 6:02:00 PM
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The A.A. Grapevine did not start publishing
until June 1944 so it is unlikely that anyone
can come up with one from 1940.
I believe the memorial issues on the deaths of
Dr. Bob and Bill W were reprinted and are still
available at private sale. The originals are
scarce and command a fairly high price.
I am not aware of any other reproduced issues.
The complete digital archive of Grapevines going
back to June 1944 is available online:
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